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The most commonly used first-line AIDS treatment in developing countries includes the drug stavudine, also known as d4t. This drug can cause a variety of side-effects in patients, including neuropathy and lipoatrophy, which means that patients need to be taken off the drug. A study carried out in MSF’s HIV project in Kigali, Rwanda, and presented at the IAC in Mexico City in August 2008 showed that 16.6% of patients needed to switch to an alternative regimen due to the side effects related to stavudine.
This is just one of the challenges facing doctors and patients in treatment for HIV/AIDS.